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Furthermore, it has been shown to elevate IGF1 levels, making it a powerful tool in the pursuit of fat loss
Nausea, reflux and other gastrointestinal effects vary between medications and between people
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The PIONEER 6 trial tested cardiovascular safety but was not powered to show benefit
The decision to terminate the clinical development of Lotiglipron was based on the pharmacokinetic data from the clinical Phase 1 drug-drug interaction studies (NCT05671653 and NCT05788328), as well as the laboratory measurements of elevated transaminases in these Phase 1 studies and the ongoing Phase 2 study (NCT05579977)
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